Prognostic value of neutrophil- lymphocyte count ratio (NLCR) among adult ICU patients in comparison to APACHE II score and conventional inflammatory markers: a multi center retrospective cohort study

Abstract Background Neutrophil-lymphocyte count ratio (NLCR) has been reported as better indicator of bacteremia than procalcitonin (PCT), and more precise predictor mortality C-reactive protein (CRP) under various medical conditions. However, large controversy remains upon this topic. To address the discrepancy, our group compared efficiency NLCR with conventional inflammatory markers in predicting prognosis critical illness. Methods We performed a multi-center retrospective cohort study involving 536 ICU patients outcomes survival, 28- 7-day mortality. was such PCT, CRP, serum lactate (LAC), white blood cell, neutrophil severity score APACHE II (Acute Physiology Chronic Health Evaluation II) to evaluate potential Then, receiver operating characteristics (ROC) curves were constructed assess compare each marker’s sensitivity specificity respectively. Results values not different between survival groups. Meanwhile, remarkable differences observed score, PCT LAC levels death ROC analysis revealed that competent predict The AUROCs effective Conclusions is less reliable assessing